萘啶酸与乳酸性酸中毒

Nalidixic acid and lactic acidosis.

作者信息

Phillips P J, Need A G, Thomas D W, Conyers R A, Edwards J B, Lehmann D

出版信息

Aust N Z J Med. 1979 Dec;9(6):694-6. doi: 10.1111/j.1445-5994.1979.tb04202.x.

DOI:10.1111/j.1445-5994.1979.tb04202.x

Abstract

Nalidixic acid may cause severe acidosis and we report a fatal case of lactic acidosis assocaited with nalidixic acid therapy. Studies in normal volunteers showed drug related impairment of lactate metabolism. We question whether the drug should be used in patients who may accumulate the drug or be predisposed to lactic acidosis.

摘要

萘啶酸可能会导致严重酸中毒，我们报告了一例与萘啶酸治疗相关的乳酸酸中毒致死病例。对正常志愿者的研究显示药物对乳酸代谢有损害。我们质疑该药物是否应用于可能会蓄积该药物或易发生乳酸酸中毒的患者。