Stolen J S, Draxler S, Nagle J J
Immunol Commun. 1984;13(3):245-53. doi: 10.3109/08820138409025465.
The kinetics of the temperature-mediated immunomodulation of the humoral antibody response to an erythrocyte antigen was remarkably different in two species of a marine teleost, the winter flounder (Pseudopleuronectes americanus) and the summer flounder (Paralichthys dentatus). These two species were caught in the same area, maintained under the same conditions and injected with the same antigen (horse red blood cells). Experiments were performed at 8, 12 and 17 degrees C during the same time of the year. Summer flounder showed only a delay in the appearance of circulating antibody at lower temperatures while winter flounder showed both a delay and a marked suppression at lower temperatures. Antibody titers remained high for over three months in summer flounder while in winter flounder antibody levels began decreasing after one month.
在两种海洋硬骨鱼——冬比目鱼（美洲拟庸鲽）和夏比目鱼（犬齿牙鲆）中，温度介导的对红细胞抗原的体液抗体反应的免疫调节动力学存在显著差异。这两种鱼在同一区域捕获，在相同条件下饲养，并注射相同抗原（马红细胞）。在一年中的同一时间于8℃、12℃和17℃进行实验。夏比目鱼在较低温度下仅表现出循环抗体出现延迟，而冬比目鱼在较低温度下既表现出延迟又表现出明显的抑制。夏比目鱼的抗体滴度在三个多月内一直很高，而冬比目鱼的抗体水平在一个月后开始下降。
