马来布鲁线虫微丝蚴血症患者中阻断因子的存在情况。
The presence of blocking factors in Brugia malayi microfilaraemic patients.
作者信息
Sim B K, Kwa B H, Mak J W
出版信息
Immunology. 1984 Jul;52(3):411-6.
Abstract
Serum from microfilaraemic patients have been shown to be unable to promote the antibody-dependent, cell-mediated adherence reaction to infective larvae of Brugia malayi in vitro. In this study, it was found that peripheral leucocytes from microfilaraemic patients were also incapable of promoting the adherence reaction even when incubated with serum of tropical pulmonary eosinophilia (TPE) patients. The TPE sera would normally promote the most intense adherence reaction. It was further shown that preincubation of normal human peripheral leucocytes with sera of microfilaraemic patients would similarly render them incapable of adherence. Such preliminary studies suggest that blocking factors may be present in microfilaraemic patients.
摘要
微丝蚴血症患者的血清已被证明在体外无法促进针对马来布鲁线虫感染性幼虫的抗体依赖性细胞介导黏附反应。在本研究中，发现微丝蚴血症患者的外周白细胞即使与热带肺嗜酸性粒细胞增多症（TPE）患者的血清一起孵育，也同样无法促进黏附反应。TPE血清通常会促进最强烈的黏附反应。进一步研究表明，正常人外周白细胞与微丝蚴血症患者的血清预孵育后，同样会使其失去黏附能力。这些初步研究表明，微丝蚴血症患者体内可能存在阻断因子。
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