McCruden A B, Stimson W H
Immunol Lett. 1984;8(1):49-53. doi: 10.1016/0165-2478(84)90104-4.
An androgen binding species has been identified in partially purified cytosol from human thymic tissue, resolved from sex steroid binding globulin by gel chromatography. This putative 5 alpha-dihydrotestosterone receptor was characterised by high affinity (Kd 6.7 X 10(-10) M) and low capacity (9 fmol/mg of cytosol protein). High affinity binding was confirmed with methyltrienolone (R1881). Competition studies were carried out with a number of androgenic compounds and 5 alpha-19 nordihydrotestosterone was shown to possess the highest affinity for the androgen receptor.
在人胸腺组织部分纯化的胞质溶胶中鉴定出一种雄激素结合物质，通过凝胶色谱法与性类固醇结合球蛋白分离。这种假定的5α-双氢睾酮受体的特征是高亲和力（解离常数Kd为6.7×10⁻¹⁰ M）和低容量（9飞摩尔/毫克胞质溶胶蛋白）。用甲基三烯醇酮（R1881）证实了高亲和力结合。用多种雄激素化合物进行了竞争研究，结果表明5α-19-去甲二氢睾酮对雄激素受体具有最高的亲和力。
