雄激素受体通过调节先天和适应性免疫系统对身体防御系统的影响：来自条件性 AR 敲除小鼠的教训。
Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice.
机构信息
George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York, USA.
出版信息
Am J Pathol. 2012 Nov;181(5):1504-12. doi: 10.1016/j.ajpath.2012.07.008. Epub 2012 Sep 4.
Abstract
Upon insult, such as infection or tissue injury, the innate and adaptive immune systems initiate a series of responses to defend the body. Recent studies from immune cell-specific androgen receptor (AR) knockout mice demonstrated that androgen and its receptor (androgen/AR) play significant roles in both immune regulations. In the innate immunity, androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulates wound healing processes through macrophage recruitment and proinflammatory cytokine production. In adaptive immunity, androgen/AR exerts suppressive effects on development and activation of T and B cells. Removal of such suppression causes thymic enlargement and excessive export of immature B cells. Altogether, androgen/AR plays distinct roles in individual immune cells, and targeting androgen/AR may help in treatment and management of immune-related diseases.
摘要
受到侮辱时，如感染或组织损伤，先天和适应性免疫系统会启动一系列反应来保护身体。最近来自免疫细胞特异性雄激素受体 (AR) 敲除小鼠的研究表明，雄激素及其受体 (雄激素/AR) 在免疫调节中发挥重要作用。在先天免疫中，雄激素/AR 是中性粒细胞生成和正常功能所必需的；雄激素/AR 还通过招募巨噬细胞和产生促炎细胞因子来调节伤口愈合过程。在适应性免疫中，雄激素/AR 对 T 和 B 细胞的发育和激活具有抑制作用。这种抑制作用的消除会导致胸腺增大和不成熟 B 细胞的过度输出。总的来说，雄激素/AR 在单个免疫细胞中发挥不同的作用，靶向雄激素/AR 可能有助于治疗和管理与免疫相关的疾病。
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