Thorpe S M, Briand P
Int J Cancer. 1984 Jul 15;34(1):127-31. doi: 10.1002/ijc.2910340122.
We have previously shown that hormone-dependent (HD) but not hormone-independent (HI) mammary tumors of GR mice concentrate iodide. Since hormone dependence is lost during serial transplantation of the tumors, we have investigated whether the ability to concentrate iodide is lost simultaneously. All tumors progressing to hormone independence lost the ability to concentrate iodide at the time of transition from the HD to the HI state. We believe, therefore, that the ability to concentrate iodide is a marker of hormone dependence in GR mouse mammary tumors.
我们之前已经表明，GR小鼠的激素依赖性（HD）乳腺肿瘤而非激素非依赖性（HI）乳腺肿瘤会聚集碘化物。由于肿瘤在连续移植过程中会失去激素依赖性，我们研究了聚集碘化物的能力是否会同时丧失。所有转变为激素非依赖性的肿瘤在从HD状态转变为HI状态时，都失去了聚集碘化物的能力。因此，我们认为聚集碘化物的能力是GR小鼠乳腺肿瘤中激素依赖性的一个标志。
