Lyttle C R, Thorpe S M, DeSombre E R, Daehnfeldt J L
J Natl Cancer Inst. 1979 Apr;62(4):1031-4.
Transplanted mammary tumors growing in the inbred GR/AFib mouse were assayed for peroxidase activity and ability to concentrate injected 125I. Both tumor peroxidase activity and iodide uptake were about ten times greater in the hormone-resonsive (HR) tumors than in the hormone-independent tumors. However, although peroxidases are known for their ability to participate in the iodination of proteins, over 90% of the radioactive iodine found in the tumors was shown to be free iodide. This finding suggests that these two parameters may be independent of each other, but both are higher in HR tumors.
对在近交系GR/AFib小鼠体内生长的移植性乳腺肿瘤进行过氧化物酶活性和摄取注入的125I能力的检测。激素反应性（HR）肿瘤中的肿瘤过氧化物酶活性和碘摄取量均比激素非依赖性肿瘤高约10倍。然而，尽管已知过氧化物酶具有参与蛋白质碘化的能力，但肿瘤中发现的超过90%的放射性碘被证明是游离碘化物。这一发现表明这两个参数可能相互独立，但在HR肿瘤中两者均较高。
