Kuzuya F, Sugino N, Yoshizumi K, Goto U, Oshima K
Int J Clin Pharmacol Ther Toxicol. 1984 Jun;22(6):291-9.
In this study, 60 mg of Azosemide and 40 mg of Furosemide were each administered to 2 volunteer persons. The daily urine volume after administration of both drugs was almost the same. Azosemide didn't show such rapid diuretic effect as was seen in Furosemide, but Azosemide proved to have a mild diuretic and protracted effect as compared with Furosemide. The influence on a daily urinary and fecal excretion of electrolyte and the decrease of serum electrolytes proved to be the same in administration of either drug. However, in the case of Furosemide, most of the electrolytes were excreted within 3 hours after administration, while Azosemide showed mild and prolonged excretion. The effect of both drugs on serum uric acid was almost the same showing a slightly rising trend.
在本研究中，给2名志愿者分别服用60毫克阿佐塞米和40毫克呋塞米。两种药物给药后的日尿量几乎相同。阿佐塞米没有表现出呋塞米那样迅速的利尿作用，但与呋塞米相比，阿佐塞米被证明具有温和且持久的利尿作用。两种药物给药后对每日尿和粪便中电解质排泄的影响以及血清电解质的降低情况被证明是相同的。然而，就呋塞米而言，大部分电解质在给药后3小时内排出，而阿佐塞米则表现出温和且持续的排泄。两种药物对血清尿酸的影响几乎相同，均呈略有上升的趋势。
