Kuzuya F
Int J Clin Pharmacol Ther Toxicol. 1983 Jan;21(1):10-23.
Single and multiple doses of SK-110 were administered orally to healthy volunteers. No subjective or objective symptoms were observed in tests I-I, I-II, I-III, and II, with the exception of dehydration, considered to be a direct effect of the diuretic, which was observed in test I-III. No noteworthy abnormalities were observed in laboratory examinations. One hour after administration of SK-110, urinary output and excretion of urinary electrolytes increased. In test II the diuretic effect of SK-110 continued for about 9 h after administration. Plasma concentration of SK-110 increased in proportion to the doses, and peak concentration was observed 3-4 h after administration. Plasma concentration of SK-110 on the 1st and 5th day of administration showed the same patterns. Drug excretion in the urine was less than 10%.
向健康志愿者口服单剂量和多剂量的SK - 110。在试验I - I、I - II、I - III和II中，除了在试验I - III中观察到的被认为是利尿剂直接作用的脱水现象外，未观察到主观或客观症状。实验室检查未发现值得注意的异常。服用SK - 110一小时后，尿量和尿电解质排泄增加。在试验II中，SK - 110的利尿作用在给药后持续约9小时。SK - 110的血浆浓度与剂量成正比，给药后3 - 4小时观察到峰值浓度。给药第1天和第5天SK - 110的血浆浓度呈现相同模式。尿液中的药物排泄量不到10%。
