Parish C R, Rylatt D B, Snowden J M
J Cell Sci. 1984 Apr;67:145-58. doi: 10.1242/jcs.67.1.145.
Cholate extracts of murine lymphocytes were shown to contain haemagglutinating activity against autologous erythrocytes. The species specificity and sugar inhibition pattern of the haemagglutinin closely paralleled the specificity of autorosetting, an interaction that had been shown previously to involve the recognition by lymphocytes of carbohydrate structures on autologous erythrocytes. The probable identity of the haemagglutinin and autorosetting receptors was confirmed by experiments utilizing the unique plasma protein autorosette inhibition factor, which appears to block both interactions by masking carbohydrate acceptor sites on erythrocytes. Detailed sugar inhibition studies revealed that the haemagglutinin and autorosetting receptors have a high affinity for certain sulphated polysaccharides, such as heparin and dextran sulphate. Since similar sulphated polysaccharides have been shown previously to inhibit lymphocyte recirculation, a possible role for these receptors in lymphocyte homing and recirculation is discussed.
小鼠淋巴细胞的胆酸盐提取物显示出对自身红细胞的血凝活性。血凝素的物种特异性和糖抑制模式与自身凝集的特异性密切平行，先前已表明这种相互作用涉及淋巴细胞对自身红细胞上碳水化合物结构的识别。利用独特的血浆蛋白自身凝集抑制因子进行的实验证实了血凝素和自身凝集受体可能具有同一性，该因子似乎通过掩盖红细胞上的碳水化合物受体位点来阻断这两种相互作用。详细的糖抑制研究表明，血凝素和自身凝集受体对某些硫酸化多糖，如肝素和硫酸葡聚糖，具有高亲和力。由于先前已表明类似的硫酸化多糖可抑制淋巴细胞再循环，因此讨论了这些受体在淋巴细胞归巢和再循环中的可能作用。
