低前列腺素浓度会导致心律紊乱。低水平的铜或氯喹可逆转这种效应。

Low prostaglandin concentrations cause cardiac rhythm disturbances. Effect reversed by low levels of copper or chloroquine.

作者信息

Swift A, Karmazyn M, Horrobin D F, Manku M S, Karmali R A, Morgan R O, Ally A I

出版信息

Prostaglandins. 1978 Apr;15(4):651-7. doi: 10.1016/0090-6980(78)90061-8.

Abstract

In perfused male rat hearts concentrations of prostaglandins (PGs) E2 and F2alpha in the range 1 pg/ml to 10 ng/ml (2.8 X 10(-12) to 2.8 X 10(-8)M) consistently caused rhythm irregularities. Higher concentrations had no effect themselves and stabilized rhythm in hearts made unstable by lower concentrations. Copper ions (as the sulphate) at 2 X 10(-6)M stabilized hearts made unstable by PGs and when present prior to the PGs prevented PG induced disturbances. Chloroquine also reversed PG-induced rhythm changes.

摘要

在灌注的雄性大鼠心脏中，前列腺素（PGs）E2和F2α浓度在1皮克/毫升至10纳克/毫升（2.8×10⁻¹²至2.8×10⁻⁸摩尔/升）范围内时，始终会引起节律异常。更高的浓度本身并无作用，但能使因较低浓度而变得不稳定的心脏节律稳定下来。2×10⁻⁶摩尔/升的铜离子（以硫酸盐形式）能使因PGs而变得不稳定的心脏稳定下来，并且在PGs之前存在时可防止PGs诱导的紊乱。氯喹也能逆转PGs诱导的节律变化。