Kondo K, Okuno T, Saruta T, Kato E
Prostaglandins. 1979 May;17(5):769-74. doi: 10.1016/s0090-6980(79)80049-0.
The effects of intraventricularly administered prostaglandins I2 (PGI2), E2 (PGE2), F2alpha (PGF2 alpha) and indomethacin on systemic blood pressure were investigated in conscious rats. PGI2 (1.25--10 micrograms/kg) decreased blood pressure in a dose-related manner, whereas PGE2 (100--1000 mg/kg) dose-dependently increased blood pressure. Both PGF2 alpha (0.31--20 micrograms/kg) and indomethacin (0.625--40 micrograms/kg) had no effects on blood pressure. These results indicate that intraventricular injection of PGI2 or PGE2 can induce significant changes in blood pressure, while endogenous prostaglandins synthesized in the brain seem to play a minor role in direct regulation of systemic blood pressure in the rat.
在清醒大鼠中研究了脑室内注射前列腺素I2（PGI2）、E2（PGE2）、F2α（PGF2α）和吲哚美辛对全身血压的影响。PGI2（1.25 - 10微克/千克）以剂量相关的方式降低血压，而PGE2（100 - 1000毫克/千克）剂量依赖性地升高血压。PGF2α（0.31 - 20微克/千克）和吲哚美辛（0.625 - 40微克/千克）对血压均无影响。这些结果表明，脑室内注射PGI2或PGE2可引起血压的显著变化，而脑内合成的内源性前列腺素在大鼠全身血压的直接调节中似乎起次要作用。
