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用于肿瘤扫描的103钌——荷瘤动物体内氯化103钌和柠檬酸103钌组织分布的比较研究(作者译)

[103Ru for tumor scanning--a comparative study on tissue distributions of 103Ru-chloride and 103Ru-citrate in tumor-bearing animals (author's transl)].

作者信息

Mizukawa K, Yamamoto G, Tamai T, Tanabe M, Yamamoto M

出版信息

Radioisotopes. 1978 May;27(5):245-50.

PMID:674703
Abstract

Biological distribution of 103Ru in mice bearing Ehlrich's solid tumor and rats bearing AH-130 solid tumor were studied with two compounds of 103Ru, the chloride and citrate. The radioactivity of 103Ru-chloride showed slower excretion and higher tumor concentration than that of citrate. The tumor-to-muscle ratios of chloride were always higher, but the tumor-to-blood ratios were always lower than those of citrate. No significant difference was founds between 103Ru-chloride and citrate as tumor scanning agents.

摘要

用两种¹⁰³Ru化合物(氯化物和柠檬酸盐)研究了¹⁰³Ru在荷艾氏实体瘤小鼠和荷AH - 130实体瘤大鼠体内的生物学分布。¹⁰³Ru氯化物的放射性排泄比柠檬酸盐慢,肿瘤摄取浓度比柠檬酸盐高。氯化物的肿瘤与肌肉比值总是更高,但肿瘤与血液比值总是低于柠檬酸盐。作为肿瘤扫描剂,¹⁰³Ru氯化物和柠檬酸盐之间未发现显著差异。

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