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用于肿瘤扫描的103钌——荷瘤动物体内氯化103钌和柠檬酸103钌组织分布的比较研究(作者译)

[103Ru for tumor scanning--a comparative study on tissue distributions of 103Ru-chloride and 103Ru-citrate in tumor-bearing animals (author's transl)].

作者信息

Mizukawa K, Yamamoto G, Tamai T, Tanabe M, Yamamoto M

出版信息

Radioisotopes. 1978 May;27(5):245-50.

PMID:674703
Abstract

Biological distribution of 103Ru in mice bearing Ehlrich's solid tumor and rats bearing AH-130 solid tumor were studied with two compounds of 103Ru, the chloride and citrate. The radioactivity of 103Ru-chloride showed slower excretion and higher tumor concentration than that of citrate. The tumor-to-muscle ratios of chloride were always higher, but the tumor-to-blood ratios were always lower than those of citrate. No significant difference was founds between 103Ru-chloride and citrate as tumor scanning agents.

摘要

用两种¹⁰³Ru化合物(氯化物和柠檬酸盐)研究了¹⁰³Ru在荷艾氏实体瘤小鼠和荷AH - 130实体瘤大鼠体内的生物学分布。¹⁰³Ru氯化物的放射性排泄比柠檬酸盐慢,肿瘤摄取浓度比柠檬酸盐高。氯化物的肿瘤与肌肉比值总是更高,但肿瘤与血液比值总是低于柠檬酸盐。作为肿瘤扫描剂,¹⁰³Ru氯化物和柠檬酸盐之间未发现显著差异。

相似文献

1
[103Ru for tumor scanning--a comparative study on tissue distributions of 103Ru-chloride and 103Ru-citrate in tumor-bearing animals (author's transl)].用于肿瘤扫描的103钌——荷瘤动物体内氯化103钌和柠檬酸103钌组织分布的比较研究(作者译)
Radioisotopes. 1978 May;27(5):245-50.
2
Tissue distributions of 97Ru and 103Ru in subcutaneous tumor of rodents.97Ru和103Ru在啮齿动物皮下肿瘤中的组织分布。
Acta Med Okayama. 1975 Dec;29(6):431-6.
3
Distribution of 103Ru-chloride in tumor-bearing animals and the mechanism for accumulation in tumor and liver.103Ru-氯化物在荷瘤动物体内的分布及其在肿瘤和肝脏中蓄积的机制。
Int J Rad Appl Instrum B. 1988;15(2):133-40. doi: 10.1016/0883-2897(88)90079-7.
4
Biochemistry of metalocenes. I. Distribution of 59Fe or 103Ru-labeled metalocene carboxylic acid in mice.二茂金属的生物化学。I. 59Fe或103Ru标记的二茂金属羧酸在小鼠体内的分布。
J Nucl Med. 1977 Apr;18(4):367-72.
5
[Influence of steroid hormones on drug disposition? Experiments with acetylruthenocene in mice and rats].[类固醇激素对药物处置的影响?小鼠和大鼠体内乙酰钌茂的实验]
Hoppe Seylers Z Physiol Chem. 1982 Jul;363(7):693-9.
6
Biochemistry of metalocenes. The organ distribution of hydroxyacetyl [103Ru]ruthenocene and its glucuronide in mice.金属茂的生物化学。羟基乙酰基[103Ru]钌茂及其葡糖醛酸苷在小鼠体内的器官分布。
J Nucl Med. 1980 Jan;21(1):63-6.
7
[A preliminary study of 57Ca-zhengguangmycin distribution in tumor-bearing mice and in clinical scanning (author's transl)].57钙-争光霉素在荷瘤小鼠体内分布及临床扫描的初步研究(作者译)
Zhonghua Zhong Liu Za Zhi. 1979;1(2):106-12.
8
[Biochemistry of metallocenes, II. Organ-distribution and thymus affinity of cinnamoyl-[103Ru]ruthenocene (author's transl)].[二茂金属的生物化学,II. 肉桂酰-[103Ru]二茂钌的器官分布及胸腺亲和性(作者译)]
Z Naturforsch C Biosci. 1977 Jul-Aug;32(7-8):473-81.
9
Autoradiographical investigations on the affinity of acetyl-(103Ru)-ruthenocene for the adrenal glands of mice.关于乙酰基 -(103钌)- 二茂钌对小鼠肾上腺亲和力的放射自显影研究。
Eur J Nucl Med. 1985;10(1-2):56-9. doi: 10.1007/BF00261764.
10
[The influence of iron on 67Ga distribution in tumor-bearing mice--effect of iron administered before 67Ga injection (author's transl)].铁对荷瘤小鼠体内67镓分布的影响——67镓注射前给予铁的效应(作者译)
Radioisotopes. 1981 Jul;30(7):379-84.