Miyata Y, Furugouri K, Shijimaya K
J Dairy Sci. 1984 Jun;67(6):1256-63. doi: 10.3168/jds.S0022-0302(84)81432-0.
Serum ferritin concentration of nursing calves was measured by a two-site immunoradiometric assay to assess developmental changes and to evaluate relationships of serum ferritin with iron-related blood characteristics. Serum ferritin concentration of calves was low at birth and elevated slightly at 3 days of age. From 1 wk of age onward, serum ferritin concentration of untreated calves and calves fed only whole milk for 4 wk decreased and remained low throughout the nursing period. This finding almost coincided with hematological characteristics. However, that nearly normal hematological measures and weight gain persisted and that they did not develop any anemic symptom indicate that serum ferritin concentration is more sensitive than other hematological characteristics to iron depletion. However, serum ferritin concentration of calves administered 130 mg of ferrous fumarate (40 mg iron) daily from 3 to 22 days of age or injected with 4 ml of iron-dextran intramuscularly (400 mg iron) at 3 days and 2 wk of age increased sharply just after treatment and persisted high for 2 to 6 wk of age. However, there was large variation between animals for serum ferritin concentration. Thus, it seems likely that serum ferritin concentration is an index for monitoring prelatent iron deficiency of calves.
采用双位点免疫放射分析方法测定哺乳犊牛的血清铁蛋白浓度，以评估其发育变化，并评估血清铁蛋白与铁相关血液特征之间的关系。犊牛出生时血清铁蛋白浓度较低，3日龄时略有升高。从1周龄开始，未处理的犊牛和仅喂全脂牛奶4周的犊牛血清铁蛋白浓度下降，并在整个哺乳期保持较低水平。这一发现几乎与血液学特征相符。然而，几乎正常的血液学指标和体重增加持续存在，且未出现任何贫血症状，这表明血清铁蛋白浓度比其他血液学特征对铁缺乏更敏感。然而，从3日龄至22日龄每天给予130mg富马酸亚铁（40mg铁）的犊牛，或在3日龄和2周龄时肌肉注射4ml右旋糖酐铁（400mg铁）的犊牛，血清铁蛋白浓度在治疗后立即急剧升高，并在2至6周龄时持续保持高水平。然而，不同动物之间血清铁蛋白浓度存在较大差异。因此，血清铁蛋白浓度似乎是监测犊牛潜在缺铁的一个指标。
