Mizuta H, Yamasaki M
Nihon Seikeigeka Gakkai Zasshi. 1984 Jan;58(1):83-95.
The relaxation times of water protons were studied by nuclear magnetic resonance (NMR) method in two kinds of experimental malignant bone tumors, intramedullary transplanted VX2 carcinoma and Gardner osteosarcoma 519. The relaxation times for malignant tumor tissues were significantly elevated than those for normal bone tissues. Bone marrow sample, where VX2 carcinoma was transplanted 1 week before and included only a few scattered malignant tumor cells, showed the elevation in the relaxation times compared with that of normal bone marrow. In addition, analyses of the electrolytes and the water content of each tissue suggest that the elevation of the relaxation times is not necessarily attributable to the factor of the water content.
通过核磁共振（NMR）方法研究了两种实验性恶性骨肿瘤（髓内移植VX2癌和Gardner骨肉瘤519）中水质子的弛豫时间。恶性肿瘤组织的弛豫时间明显高于正常骨组织。在移植VX2癌1周前获取的骨髓样本，其中仅包含少数散在的恶性肿瘤细胞，与正常骨髓相比，其弛豫时间有所升高。此外，对各组织的电解质和含水量分析表明，弛豫时间的升高不一定归因于含水量因素。
