Bourgeois A, Quillard J, Constantin J M, Cottin P, Cosson J P, Le Baleur A, Bellagha I, Frileux C
J Mal Vasc. 1984;9(2):97-9.
Although accidents due to the intra-arterial injection of detergent sclerosant are very rarely observed, they are dramatic in their effects and often result in amputations, a risk accepted with difficulty for a treatment with a functional aim. To avoid these incidents, which may occur even when treatment is applied by the most experienced surgeons, the authors have used 66% glucose solution without accident since 1948. To confirm efficacy of the method, an experimental study compared 66% glucose (66 G) with a very commonly used product, 1% sodium tetradecyl sulfate (STD), in the rabbit. Except when enormous doses of 66 G are employed, the only effect noted was eosinophilic necrosis of the vessel wall without clinical symptoms, whereas doses eight times lower of STD produced an irreversible ischemia from obliterating endarteritis of the branches of the vascular tree injected. The 66% glucose solution appears to be a very safe, gently acting sclerosant, and the product of choice for peri- and post-operative sclerosis, particularly in regions where accidental arterial puncture is anatomically possible.
尽管动脉内注射硬化剂洗涤剂引起的事故非常罕见，但它们的影响却很严重，常常导致截肢，对于一种以功能为目的的治疗来说，这种风险很难被接受。为了避免这些即使是最有经验的外科医生在进行治疗时也可能发生的事故，自1948年以来，作者使用66%葡萄糖溶液未发生过意外。为了证实该方法的有效性，一项实验研究在兔子身上将66%葡萄糖（66G）与一种非常常用的产品1%十四烷基硫酸钠（STD）进行了比较。除了使用超大剂量的66G外，唯一观察到的效果是血管壁嗜酸性坏死，无临床症状，而剂量低八倍的STD则会因注射血管树分支的闭塞性动脉内膜炎而导致不可逆的缺血。66%葡萄糖溶液似乎是一种非常安全、作用温和的硬化剂，是围手术期和术后硬化治疗的首选产品，特别是在解剖学上可能发生意外动脉穿刺的区域。
