Schnurr D P, Cao Y, Schmidt N J
J Gen Virol. 1984 Jul;65 ( Pt 7):1197-201. doi: 10.1099/0022-1317-65-7-1197.
NIH(S) II nu/nu (athymic) and +/nu (euthymic) mice were inoculated with coxsackievirus B3 (CBV-3) and examined at various times after infection for virus titres in the heart, myocarditis and serum neutralizing antibodies. Virus was recovered from the hearts of nu/nu mice for up to 94 days post-inoculation, but was not recovered from the hearts of any +/nu mice beyond 14 days. Inflammatory cell infiltration and necrosis were present in the hearts of +/nu mice at all harvest times (7, 14, 21 and 28 days). Inflammation and necrosis did not become evident in nu/nu mice until 14 days post-inoculation, and was the present in mice from each harvest until the end of the experiment (94 days). In athymic mice, myocarditis showed a strong correlation with persistence of CBV-3 in the heart. In N:NIH(S) II mice, the presence (+/nu) or absence (nu/nu) of a thymus had a major influence on the clearance of virus from the heart and on the development of myocarditis.
将无胸腺裸鼠（N:NIH(S) II nu/nu）和胸腺正常的杂合子小鼠（+/nu）接种柯萨奇病毒B3（CBV - 3），并在感染后的不同时间检查心脏中的病毒滴度、心肌炎情况以及血清中和抗体。在接种后长达94天的时间里，能从无胸腺裸鼠的心脏中分离出病毒，但在14天后，未从任何胸腺正常的杂合子小鼠心脏中分离出病毒。在所有采集时间点（7天、14天、21天和28天），胸腺正常的杂合子小鼠心脏中均存在炎性细胞浸润和坏死。无胸腺裸鼠直到接种后14天才出现明显的炎症和坏死，且在每个采集时间点的小鼠中均有出现，直至实验结束（94天）。在无胸腺小鼠中，心肌炎与CBV - 3在心脏中的持续存在密切相关。在N:NIH(S) II小鼠中，胸腺的存在（+/nu）或缺失（nu/nu）对心脏中病毒的清除以及心肌炎的发展有重大影响。
