Brommage R, DeLuca H F
J Nutr. 1984 Aug;114(8):1377-85. doi: 10.1093/jn/114.8.1377.
Lactating and nonlactating rats, both deficient and replete in cholecalciferol, were allowed a free selection among three diets containing 0.47% Ca, 0.3% P (normal Ca, normal P diet); 2.0% Ca, 0.3% P (high Ca diet); and 0.47% Ca, 1.0% P (high P diet). An additional group of vitamin D-deficient lactating rats was fed only the normal Ca, normal P diet. Vitamin D-deficient rats showed a strong selection preference for the high Ca diet but avoided the high P diet, whereas cholecalciferol-replete rats consumed the normal Ca, normal P diet predominantly. Compared to the nonselecting rats, the selection of the high Ca diet by the lactating rats deficient in vitamin D resulted in an increase in plasma calcium levels, hypophosphatemia, a doubling of food consumption, a reduction in maternal body weight loss and a stimulation of milk production as indicated by pup growth. These results demonstrate that vitamin D-deficient rats select a high Ca diet and that the decrease in milk production found in vitamin D deficiency results from a decrease in food consumption and that this anorexia is at least partially dependent on the hypocalcemia normally occurring in vitamin D deficiency.
给泌乳和非泌乳大鼠（维生素D缺乏和充足的都有）提供三种日粮供其自由选择，这三种日粮分别含0.47%钙、0.3%磷（正常钙、正常磷日粮）；2.0%钙、0.3%磷（高钙日粮）；以及0.47%钙、1.0%磷（高磷日粮）。另外一组维生素D缺乏的泌乳大鼠只喂正常钙、正常磷日粮。维生素D缺乏的大鼠对高钙日粮表现出强烈的选择偏好，但回避高磷日粮，而维生素D充足的大鼠则主要食用正常钙、正常磷日粮。与无选择行为的大鼠相比，维生素D缺乏的泌乳大鼠选择高钙日粮后，血浆钙水平升高，出现低磷血症，食物摄入量增加一倍，母体体重减轻减少，并且如幼崽生长所示，乳汁分泌增加。这些结果表明，维生素D缺乏的大鼠会选择高钙日粮，维生素D缺乏时乳汁分泌减少是由于食物摄入量减少所致，并且这种厌食至少部分取决于维生素D缺乏时通常会出现的低钙血症。
