Forbes R M, Parker H M, Erdman J W
J Nutr. 1984 Aug;114(8):1421-5. doi: 10.1093/jn/114.8.1421.
Young rats were fed diets containing 12 mg Zn/kg and varied levels of sodium phytate for 21-day ad libitum feeding periods. In experiment 1, Ca levels were 0.3, 0.5, 0.8 and 1.0%, and phytate:Zn molar ratio varied between 0 and 50. In experiment 2, Ca was maintained at 0.3%, Mg levels were 0.07, 0.22 and 0.37%, and phytate:Zn molar ratios were 0, 10, 20 and 30 at each Mg level. Major response criteria were body weight gain and tibia Zn accumulation. Weight gain was not influenced by Ca level in the absence of phytate or by phytate at 0.3% Ca; it was increasingly depressed as phytate was increased and by each increase in Ca in the presence of phytate. Total tibia Zn content was decreased at the highest Ca level in the absence of phytate; increasing the phytate progressively depressed tibia Zn at all Ca levels. Mg and phytate additions did not affect weight gain. Tibia Zn tended to be depressed by Mg and by phytate but these effects were significant only at the highest levels of the combined additions. These data corroborate and extend previously published findings on Ca and phytate effects on Zn utilization and show bone Zn accumulation to be a more sensitive criterion than weight gain in this connection. They also indicate that Mg exerts a less pronounced effect on Zn utilization in phytate-containing diets than does Ca.
给幼鼠喂食含12毫克锌/千克以及不同水平植酸钠的日粮，自由采食21天。在实验1中，钙水平分别为0.3%、0.5%、0.8%和1.0%，植酸与锌的摩尔比在0至50之间变化。在实验2中，钙维持在0.3%，镁水平分别为0.07%、0.22%和0.37%，在每个镁水平下，植酸与锌的摩尔比分别为0、10、20和30。主要的反应指标是体重增加和胫骨锌蓄积。在没有植酸的情况下，体重增加不受钙水平的影响，在钙水平为0.3%时也不受植酸的影响；随着植酸增加以及在有植酸存在时钙的每次增加，体重增加逐渐受到抑制。在没有植酸的情况下，最高钙水平时胫骨锌的总含量降低；在所有钙水平下，植酸增加都会使胫骨锌含量逐渐降低。添加镁和植酸对体重增加没有影响。镁和植酸倾向于降低胫骨锌含量，但这些影响仅在两者添加量最高时才显著。这些数据证实并扩展了先前发表的关于钙和植酸对锌利用影响的研究结果，表明在这方面，骨骼锌蓄积是比体重增加更敏感的指标。它们还表明，在含植酸的日粮中，镁对锌利用的影响不如钙明显。
