Ribaya-Mercado J D, Gershoff S N
J Nutr. 1984 Aug;114(8):1447-53. doi: 10.1093/jn/114.8.1447.
Rats fed diets containing galactose as the source of carbohydrate excreted greater amounts of endogenously formed oxalic acid in their urine, compared to rats fed glucose, fructose or sucrose. Rats fed lactose showed similar but less marked effects. The greatest amounts of urinary and fecal oxalate excretions were observed among rats fed galactose and no vitamin B-6. This group had the lowest body weights after 3 weeks of feeding. Control rats fed galactose or lactose diets weighed less than those fed sucrose, glucose or fructose diets. All rats fed galactose developed cataracts. More [14C]oxalic acid was recovered in the urine and kidneys of control rats injected with D-[U-14C]galactose compared to those injected with D-[U-14C]glucose or D-[U-14C]fructose. Similar results were observed in kidneys of vitamin B-6-deficient rats. The possible mechanisms by which galactose and other sugars may be converted to oxalate are discussed.
与喂食葡萄糖、果糖或蔗糖的大鼠相比，喂食以半乳糖为碳水化合物来源的日粮的大鼠，尿中内源性生成的草酸排泄量更多。喂食乳糖的大鼠表现出类似但不太明显的影响。在喂食半乳糖且缺乏维生素B-6的大鼠中，观察到尿草酸和粪草酸排泄量最大。该组在喂食3周后体重最低。喂食半乳糖或乳糖日粮的对照大鼠比喂食蔗糖、葡萄糖或果糖日粮的大鼠体重轻。所有喂食半乳糖的大鼠都出现了白内障。与注射D-[U-¹⁴C]葡萄糖或D-[U-¹⁴C]果糖的对照大鼠相比，注射D-[U-¹⁴C]半乳糖的对照大鼠的尿液和肾脏中回收的[¹⁴C]草酸更多。在维生素B-6缺乏的大鼠肾脏中也观察到类似结果。本文讨论了半乳糖和其他糖类可能转化为草酸盐的潜在机制。
