Ono H, Fukuda H, Kudo Y
J Pharmacobiodyn. 1984 Mar;7(3):171-6. doi: 10.1248/bpb1978.7.171.
The participation of local anesthetic action in spinal reflex inhibition produced by mephenesin-type muscle relaxants was examined by comparing the local anesthetic effects (in vitro), the depressant effects on muscle afferent discharges (in situ) and the depressant effects on spinal reflexes (in situ) of the drugs in rats. At doses producing depression of spinal reflexes, mephenesin, tolperisone (mephenesin-type) and lidocaine (local anesthetic) reduced the frequency of afferent discharges from the muscle. The order of reducing afferent discharges by these drugs corresponded to that of their conduction blocking activities in the isolated sciatic nerve of rats. These results suggest the participation of a membrane stabilizing action in spinal reflex inhibition produced by mephenesin-type muscle relaxants. Baclofen (non-mephenesin-type) did not show any local anesthetic action.
通过比较大鼠体内药物的局部麻醉作用（体外）、对肌肉传入放电的抑制作用（原位）以及对脊髓反射的抑制作用（原位），研究了局部麻醉作用在甲丙氨酯类肌肉松弛剂产生的脊髓反射抑制中的参与情况。在产生脊髓反射抑制的剂量下，甲丙氨酯、托哌酮（甲丙氨酯类）和利多卡因（局部麻醉剂）降低了肌肉传入放电的频率。这些药物减少传入放电的顺序与其在大鼠离体坐骨神经中的传导阻断活性顺序一致。这些结果表明，膜稳定作用参与了甲丙氨酯类肌肉松弛剂产生的脊髓反射抑制。巴氯芬（非甲丙氨酯类）未表现出任何局部麻醉作用。
