Rosecrans J A, Chance W T, Spencer R M
Res Commun Chem Pathol Pharmacol. 1978 May;20(2):221-37.
Rats learned to discriminate cyclazocine (2 mg/kg, i.p.) from saline using a two-lever operant (FR-4) procedure within 10 sessions under each drug condition. The cyclazocine discriminative stimulus (DS) was both dose- and time-related, being antagonized by naloxone at doses approximately 80 times that necessary to block the discriminative stimulus effect of morphine. Cyclazocine also generalized to nalorphine, but not to morphine, pentazocine or LSD. These data suggest that cyclazocine produced DS control of behavior by acting at CNS sites different from those affected by morphine or LSD.
大鼠在每种药物条件下的10次实验中，通过双杠杆操作性（固定比率4）程序学会了区分环唑辛（2毫克/千克，腹腔注射）和生理盐水。环唑辛的辨别性刺激（DS）与剂量和时间相关，纳洛酮能拮抗其作用，所需剂量约为阻断吗啡辨别性刺激效应所需剂量的80倍。环唑辛也能与烯丙吗啡产生交叉反应，但与吗啡、喷他佐辛或麦角酸二乙酰胺无交叉反应。这些数据表明，环唑辛通过作用于与吗啡或麦角酸二乙酰胺所影响的中枢神经系统部位不同的位点，对行为产生辨别性刺激控制。
