Morita S
Jpn J Pharmacol. 1984 Jun;35(2):143-51. doi: 10.1254/jjp.35.143.
Uptake of Cd2+ by the liver and kidney of female mice 24 hr after challenge with a large dose of Cd2+ (100 mg Cd2+/kg, p.o.) was greatly reduced by pretreatment with a small dose of the cation (15 mg Cd2+/kg, p.o.) at 24 hr (for liver) and at 6, 24 or 48 hr (for kidney) prior to the challenge dose. The hepatic concentration of Zn2+ tended to be increased by the Cd2+ challenge and was increased further by pretreatment. The renal concentration of Zn2+ was not influenced by Cd2+ administration. The retention rate of Cd2+ in the stomach and its contents 24 hr after the Cd2+ challenge was decreased by pretreatment. In addition, the excretion rate of Cd2+ into the feces 24 hr after the Cd2+ challenge was increased by pretreatment at 6 to 24 hr prior to the challenge dose. Consequently, the absorption rate of Cd2+ 24 hr after the Cd2+ challenge was markedly reduced by pretreatment at 24 hr prior to the challenge dose. The urinary and biliary excretion of Cd2+ was very low. The motility of the small intestine was stimulated 6 hr after a small dose of Cd2+, but returned to normal within 24 hr. The motility tended to be reduced 4 hr after the Cd2+ challenge, but conversely, it was facilitated at 24 hr. Pretreatment at 6 or 24 hr prior to the challenge dose prevented the reduction of the motility 4 hr after the Cd2+ challenge.
用大剂量的镉（100毫克镉/千克，口服）对雌性小鼠进行攻击24小时后，肝脏和肾脏对镉的摄取量，在攻击剂量前24小时（对于肝脏）以及6、24或48小时（对于肾脏）用小剂量的阳离子（15毫克镉/千克，口服）进行预处理后，会大大降低。镉攻击会使肝脏中锌的浓度有升高趋势，预处理会使其进一步升高。镉的给药对肾脏中锌的浓度没有影响。镉攻击24小时后，胃及其内容物中镉的保留率因预处理而降低。此外，在攻击剂量前6至24小时进行预处理，会使镉攻击24小时后进入粪便的镉排泄率增加。因此，在攻击剂量前24小时进行预处理，会使镉攻击24小时后镉的吸收率显著降低。镉的尿液和胆汁排泄量非常低。小剂量镉给药6小时后，小肠的蠕动受到刺激，但在24小时内恢复正常。镉攻击4小时后，蠕动有降低趋势，但相反，在24小时时蠕动得到促进。在攻击剂量前6或24小时进行预处理可防止镉攻击4小时后蠕动降低。
