Pande J N, Guleria J S
Respiration. 1978;36(3):117-26. doi: 10.1159/000193935.
The effect of non-uniformity in the distribution of ventilation and diffusion on the apparent pulmonary diffusing capacity measured by the single breath and steady state techniques has been assessed on the basis of a two-compartmental lung model. Both the methods give reasonable estimates of the true diffusing capacity provided the fast compartment has a greater KCO. The reverse of this results in gross underestimation of the diffusing capacity by both methods. There is a fairly good correlation between the single breath and the steady state results both in theory as well as in practice.
基于双室肺模型，评估了通气和扩散分布不均匀对通过单次呼吸和稳态技术测量的表观肺扩散能力的影响。只要快室具有更高的一氧化碳弥散系数（KCO），这两种方法都能对真实扩散能力给出合理估计。反之则会导致两种方法对扩散能力的严重低估。在理论和实践中，单次呼吸结果和稳态结果之间都存在相当好的相关性。
