Banchero N, Aquin L, Romo-Salas F, Searles J M
Respiration. 1978;36(4):189-93. doi: 10.1159/000193948.
In dogs breathing spontaneously with added dead space, 198, 298 and 548 ml, the O2 consumption is a function of minute ventilation. This relationship (VO2 = 9.3 VE + 81.6; r = 0.95) was the same as that found in dogs breathing spontaneously with normal dead space. With added dead space, average tidal volumes increased but not enough to compensate for the added volume and, thus, dogs achieved alveolar ventilation mainly by using the fatest molecules of gas in the airway, because of the conical shape of the velocity profile of gas molecules. When the values for VO2 and f were grouped according to different VTS, VO2 was found to be a linear function of f. Also, for a given f, VO2 increased progressively with VT; however, the higher the f, the more taxing a given increase in VT was. Over a certain range of respiratory frequencies, dogs could reduce f and increase VT without significantly affecting VO2.
在添加了198、298和548毫升死腔的自主呼吸犬中，氧气消耗量是分钟通气量的函数。这种关系（VO2 = 9.3VE + 81.6；r = 0.95）与在具有正常死腔的自主呼吸犬中发现的关系相同。随着死腔增加，平均潮气量增加，但不足以补偿增加的容积，因此，由于气体分子速度分布呈锥形，犬主要通过利用气道中最快的气体分子来实现肺泡通气。当根据不同的潮气量对VO2和呼吸频率值进行分组时，发现VO2是呼吸频率的线性函数。同样，对于给定的呼吸频率，VO2随着潮气量的增加而逐渐增加；然而，呼吸频率越高，给定潮气量的增加所带来的负担就越大。在一定的呼吸频率范围内，犬可以降低呼吸频率并增加潮气量，而不会显著影响氧气消耗量。
