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副银屑病和蕈样肉芽肿的治疗:补骨脂素及长波紫外线A(PUVA)的作用

Treatment of parapsoriasis and mycosis fungoides: the role of psoralen and long-wave ultraviolet light A (PUVA).

作者信息

Powell F C, Spiegel G T, Muller S A

出版信息

Mayo Clin Proc. 1984 Aug;59(8):538-46. doi: 10.1016/s0025-6196(12)61492-x.

DOI:10.1016/s0025-6196(12)61492-x
PMID:6748744
Abstract

Psoralen and long-wave ultraviolet light A (PUVA) was used to treat 12 patients with parapsoriasis and 19 patients with mycosis fungoides. Excellent results were obtained in all 12 patients with parapsoriasis: 8 patients had complete clearing, 3 had more than 80% improvement, and 1 had considerable improvement. The response to PUVA in patients with mycosis fungoides varied according to the stage of the disease. Of 10 patients with early disease (stage I or II), 7 had complete clearing and the 3 others had more than 80% improvement. The nine patients with more advanced disease generally did not respond well to PUVA, with the exception of one patient with stage IV disease and one with stage V disease. PUVA may be the treatment of choice for parapsoriasis and is highly effective in the early stages of mycosis fungoides.

摘要

补骨脂素与长波紫外线A(PUVA)被用于治疗12例副银屑病患者和19例蕈样肉芽肿患者。所有12例副银屑病患者均取得了优异的治疗效果:8例患者皮损完全消退,3例改善超过80%,1例有显著改善。蕈样肉芽肿患者对PUVA的反应因疾病分期而异。10例早期疾病(Ⅰ期或Ⅱ期)患者中,7例皮损完全消退,另外3例改善超过80%。9例病情较晚期的患者对PUVA的反应通常不佳,但1例Ⅳ期患者和1例Ⅴ期患者除外。PUVA可能是副银屑病的首选治疗方法,并且在蕈样肉芽肿的早期阶段疗效显著。

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Treatment of parapsoriasis and mycosis fungoides: the role of psoralen and long-wave ultraviolet light A (PUVA).副银屑病和蕈样肉芽肿的治疗:补骨脂素及长波紫外线A(PUVA)的作用
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引用本文的文献

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Parapsoriasis-A Diagnosis with an Identity Crisis: A Narrative Review.副银屑病——一场身份危机的诊断:一篇叙述性综述
Dermatol Ther (Heidelb). 2022 May;12(5):1091-1102. doi: 10.1007/s13555-022-00716-y. Epub 2022 Apr 15.
2
Photochemotherapy. A reappraisal of its use in dermatology.光化学疗法。对其在皮肤科应用的重新评估。
Drugs. 1989 Nov;38(5):822-37. doi: 10.2165/00003495-198938050-00007.