Powell F C, Spiegel G T, Muller S A
Mayo Clin Proc. 1984 Aug;59(8):538-46. doi: 10.1016/s0025-6196(12)61492-x.
Psoralen and long-wave ultraviolet light A (PUVA) was used to treat 12 patients with parapsoriasis and 19 patients with mycosis fungoides. Excellent results were obtained in all 12 patients with parapsoriasis: 8 patients had complete clearing, 3 had more than 80% improvement, and 1 had considerable improvement. The response to PUVA in patients with mycosis fungoides varied according to the stage of the disease. Of 10 patients with early disease (stage I or II), 7 had complete clearing and the 3 others had more than 80% improvement. The nine patients with more advanced disease generally did not respond well to PUVA, with the exception of one patient with stage IV disease and one with stage V disease. PUVA may be the treatment of choice for parapsoriasis and is highly effective in the early stages of mycosis fungoides.
补骨脂素与长波紫外线A(PUVA)被用于治疗12例副银屑病患者和19例蕈样肉芽肿患者。所有12例副银屑病患者均取得了优异的治疗效果:8例患者皮损完全消退,3例改善超过80%,1例有显著改善。蕈样肉芽肿患者对PUVA的反应因疾病分期而异。10例早期疾病(Ⅰ期或Ⅱ期)患者中,7例皮损完全消退,另外3例改善超过80%。9例病情较晚期的患者对PUVA的反应通常不佳,但1例Ⅳ期患者和1例Ⅴ期患者除外。PUVA可能是副银屑病的首选治疗方法,并且在蕈样肉芽肿的早期阶段疗效显著。