体温过低大鼠肾上腺素产热效应与肾上腺髓质分泌活动的关系

Dependence of the calorigenic effect of adrenaline on the secretory activity of the adrenal medulla in posthypothermic rats.

作者信息

Davidović V, Petrović V M

出版信息

Resuscitation. 1978;6(1):59-63. doi: 10.1016/0300-9572(78)90037-0.

Abstract

Posthypothermic rats, 13 h after spontaneous rewarming as well as between days 6 and 7, produced the same quantity of heat as euthermic control animals. At the same time both urinary adrenaline excretion and adrenaline content of the adrenals were markedly changed. In the initial phase of the posthypothermic state (13 h after spontaneous rewarming) urinary adrenaline excretion was significantly increased whereas adrenaline content in the adrenals was lower than in normothermic control rats (P less than 0.001). Between days 6 and 7 after rewarming, the rate of urinary adrenaline excretion and adrenaline content in the adrenals returned to the control values. The calorigenic effect of exogenous adrenaline (50 microgram/100 g), found in the euthermic control rats, was not observed in posthypothermic animals 13 h after spontaneous rewarming when the secretory activity of the adrenal medulla was increased. The restitution of the calorigenic action of exogenous adrenaline occurred between days 6 and 7 after hypothermia.

摘要

体温过低的大鼠在自然复温13小时后以及第6至7天期间，产生的热量与正常体温的对照动物相同。与此同时，尿中肾上腺素排泄量和肾上腺中肾上腺素含量均发生了显著变化。在体温过低状态的初始阶段（自然复温13小时后），尿中肾上腺素排泄量显著增加，而肾上腺中肾上腺素含量低于正常体温的对照大鼠（P<0.001）。复温后第6至7天，尿中肾上腺素排泄率和肾上腺中肾上腺素含量恢复到对照值。在正常体温的对照大鼠中发现的外源性肾上腺素（50微克/100克）的产热作用，在自然复温13小时后的体温过低动物中未观察到，此时肾上腺髓质的分泌活性增加。外源性肾上腺素产热作用的恢复发生在体温过低后的第6至7天。