CALLINGHAM B A, MANN M
Br J Pharmacol Chemother. 1962 Feb;18(1):138-49. doi: 10.1111/j.1476-5381.1962.tb01157.x.
The effect of reserpine on the adrenaline and noradrenaline contents of rat adrenal glands has been studied. Given subcutaneously to male albino Wistar rats in 3 daily doses of 1 mg/kg, it caused, 24 hr after the final dose, a similar percentage loss of adrenaline and noradrenaline of approximately 50%. Subsequently the adrenaline content slowly increased, until at 14 days from the begining of the experiment there was no significant difference between the reserpine-treated and the control glands. In contrast, the recovery of the noradrenaline content was rapid, exceeding the control value at 7 days by approximately 250%. This increased content of noradrenaline declined to the normal level by 21 days. The total amine content returned to normal by 7 days and remained at this level subsequently. The effect of re-depleting the glands of their amine content was investigated. It was found that re-depletion at 7 days caused a preferential release of noradrenaline, followed at 14 days by a peak of noradrenaline at least as high as that obtained following the initial depletion only. Re-depletion at 21 days caused an effect similar to that obtained initially. Denervation of the left adrenal gland did not alter the degree of depletion caused by reserpine, nor did it alter the subsequent replacement of the amines as compared with that in the innervated right gland.
已对利血平对大鼠肾上腺中肾上腺素和去甲肾上腺素含量的影响进行了研究。以每日3次、每次1 mg/kg的剂量皮下注射给雄性白化Wistar大鼠，在末次给药后24小时，肾上腺素和去甲肾上腺素损失的百分比相似，约为50%。随后，肾上腺素含量缓慢增加，直到实验开始后14天，利血平处理组与对照组肾上腺之间无显著差异。相比之下，去甲肾上腺素含量恢复迅速，在7天时超过对照值约250%。这种增加的去甲肾上腺素含量在21天时降至正常水平。总胺含量在7天时恢复正常，随后保持在此水平。研究了再次耗尽肾上腺中胺含量的影响。发现7天时再次耗尽导致去甲肾上腺素优先释放，14天时去甲肾上腺素达到峰值，至少与仅初次耗尽后获得的峰值一样高。21天时再次耗尽产生的效果与最初获得的效果相似。左侧肾上腺去神经支配并未改变利血平引起的耗尽程度，与右侧有神经支配的肾上腺相比，也未改变随后胺的补充情况。
