Rice F A, McCurdy J D, Heath J R
Life Sci. 1984 Jul 30;35(5):517-23. doi: 10.1016/0024-3205(84)90245-5.
Leucogenenol a heterocyclic enolic thymothyroid hormone (MW 383) whose concentration in the serum regulates the rate at which already committed cells of the bone marrow develop into functional cells, was found to be associated in the thymus with a carrier protein. The carrier protein for leucogenenol is not precipitated by heating to 80 degrees but following this treatment leucogenenol is precipitated in association with proteins precipitated by acetone and then by saturated ammonium sulfate. On chromatography on Sephacryl G-200 it was found that leucogenenol was associated with proteins of MW approximately 38,000. Leucogenenol is not eluted from the chromatographic column if it is not associated with its carrier proteins. It is suggested that other hormones such as those associated with the reproductive cycle or compounds that result from tissue damage induce the liberation of leucogenenol from its carrier protein in the thymus to the circulation where it is associated as previously described, with a protein of approximately MW 300,000.
亮甲酚醇是一种杂环烯醇式胸腺甲状腺激素（分子量383），其血清浓度调节骨髓中已定向细胞发育为功能细胞的速率。研究发现，亮甲酚醇在胸腺中与一种载体蛋白相关联。亮甲酚醇的载体蛋白在加热至80度时不会沉淀，但在此处理后，亮甲酚醇会与丙酮沉淀的蛋白质以及随后饱和硫酸铵沉淀的蛋白质一起沉淀。在Sephacryl G - 200上进行色谱分析时发现，亮甲酚醇与分子量约为38,000的蛋白质相关联。如果亮甲酚醇不与其载体蛋白结合，它就不会从色谱柱上洗脱下来。有人提出，其他激素，如与生殖周期相关的激素或组织损伤产生的化合物，会诱导亮甲酚醇从胸腺中的载体蛋白释放到循环中，在循环中它如前所述与一种分子量约为300,000的蛋白质结合。
