Rice F A, McCurdy J D
J Immunol. 1982 Apr;128(4):1769-71.
Recent investigations in this laboratory have established that daily treatment with leucogenenol, an enolic heterocyclic hormone synthesized by the thymus and/or thyroid, induces neonatally thymectomized mice that have accepted a skin allograft to reject this allograft in 7 to 14 days. Also, daily treatment with leucogenenol causes neonatally thymectomized mice to respond to challenge with sheep erythrocytes with the formation of normal titers of hemolysin. These results demonstrate that the hormone leucogenenol induces the development of those cells, absent in neonatally thymectomized mice, that are necessary for a normal immune response.
本实验室最近的研究表明，用白细胞生成醇（一种由胸腺和/或甲状腺合成的烯醇式杂环激素）进行每日治疗，可使已接受皮肤同种异体移植的新生期胸腺切除小鼠在7至14天内排斥该同种异体移植。此外，用白细胞生成醇进行每日治疗可使新生期胸腺切除小鼠对绵羊红细胞攻击产生反应，形成正常滴度的溶血素。这些结果表明，激素白细胞生成醇可诱导新生期胸腺切除小鼠体内缺乏的、正常免疫反应所必需的细胞发育。
