Kanstrup I L, Ekblom B
Med Sci Sports Exerc. 1984 Jun;16(3):256-62.
Changes in blood volume (BV) and hemoglobin concentration ( [Hb] ) were induced in five healthy young men. After acute hypovolemic anemia was achieved by blood withdrawal, VO2max values decreased, while the same [Hb] due to acute plasma volume expansion (6% dextran) did not alter VO2max. After reinfusion of red blood cells, leading to hypervolemia and increased [Hb], VO2max increased. Plasma volume expansion in this situation, leading to hypervolemia at normal [Hb], resulted in a slight reduction in VO2max, which, however, remained elevated (approximately 4%) above control values. Physical performance, measured as time to exhaustion, corresponded to the changes in VO2max except for the hypervolemic anemic situation, where it decreased. Changes in peak heart rate were inversely related to BV changes, but were also influenced by [Hb]. The results point to a significant influence of the total amount of Hb rather than the blood hemoglobin concentration for obtaining a high maximal aerobic power. Thus, a reduced [Hb], concomitantly with an elevated blood volume (plasma volume), may result in an unchanged VO2max, but reduced performance time.
在五名健康年轻男性中诱导血容量（BV）和血红蛋白浓度（[Hb]）发生变化。通过采血造成急性低血容量性贫血后，最大摄氧量（VO2max）值下降，而因急性血浆量扩充（6%右旋糖酐）导致相同的[Hb]时，VO2max并未改变。重新输注红细胞后，导致血容量过多和[Hb]升高，VO2max增加。在这种情况下，血浆量扩充导致正常[Hb]时血容量过多，VO2max略有降低，然而，仍比对照值升高（约4%）。以力竭时间衡量的体能表现与VO2max的变化一致，但血容量过多性贫血情况除外，此时体能表现下降。峰值心率的变化与BV变化呈负相关，但也受[Hb]影响。结果表明，获得高最大有氧能力时，血红蛋白总量而非血液血红蛋白浓度有显著影响。因此，[Hb]降低，同时血容量（血浆量）升高，可能导致VO2max不变，但力竭时间缩短。
