Rothwell N J, Stock M J
Metabolism. 1984 Aug;33(8):768-71. doi: 10.1016/0026-0495(84)90220-8.
Voluntary intake of solutions of alcohol (7%) and sucrose (10%) represented 20% and 25% of total metabolizable energy intake, respectively, in young male rats maintained on a stock diet, but total energy intake was similar to that of controls drinking water. Body weight and energy gains were similar for control and sucrose-treated rats but were significantly reduced in the group drinking alcohol, and energy expenditure, corrected for body size (kJ/kg0.75/day), was elevated in rats drinking alcohol (17% above control) or sucrose (18%). Gross and net energetic efficiencies were markedly depressed by consumption of alcohol but not by consumption of sucrose. Resting oxygen consumption, before and after injection of norepinephrine (25 micrograms/100 g body weight) was similar for all groups. Brown adipose tissue (BAT) mass and mitochondrial protein did not differ between groups, but the activity of the mitochondrial proton conductance pathway, assessed from the binding of 3H-guanosine diphosphate, was significantly elevated by alcohol and sucrose consumption. Thus, the increased energy expenditure associated with alcohol and sucrose ingestion may involve BAT thermogenesis, but this alone cannot explain the larger effects of alcohol on metabolic efficiency.
在以常规饲料喂养的年轻雄性大鼠中，自愿摄入酒精溶液（7%）和蔗糖溶液（10%）分别占总可代谢能量摄入的20%和25%，但总能量摄入与饮用清水的对照组相似。对照组和蔗糖处理组大鼠的体重增加和能量增加相似，但饮酒组大鼠的体重和能量增加显著减少，且按体型校正后的能量消耗（kJ/kg0.75/天）在饮酒大鼠（比对照组高17%）或蔗糖处理大鼠（比对照组高18%）中有所升高。酒精消耗显著降低了总能量效率和净能量效率，但蔗糖消耗未产生此影响。所有组在注射去甲肾上腺素（25微克/100克体重）前后的静息氧消耗相似。各组间棕色脂肪组织（BAT）质量和线粒体蛋白无差异，但通过3H-鸟苷二磷酸结合评估的线粒体质子传导途径活性因酒精和蔗糖消耗而显著升高。因此，与酒精和蔗糖摄入相关的能量消耗增加可能涉及BAT产热，但仅此一点无法解释酒精对代谢效率的更大影响。
