Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China.
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Nutrients. 2023 Jun 29;15(13):2953. doi: 10.3390/nu15132953.
According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact on the pathogenesis of alcoholic liver disease. There has been increasing recognition of the crucial role of adipose tissue in regulating systemic metabolism, far beyond that of an inert energy storage organ in recent years. The endocrine function of adipose tissue is widely recognized, and the significance of the proteins it produces and releases is still being investigated. Alcohol consumption may affect white adipose tissue (WAT) and brown adipose tissue (BAT), which interact with surrounding tissues such as the liver and intestines. This review briefly introduces the basic concept and classification of adipose tissue and summarizes the mechanism of alcohol affecting lipolysis and lipogenesis in WAT and BAT. The adipose tissue-liver axis is crucial in maintaining lipid homeostasis within the body. Therefore, this review also demonstrates the effects of alcohol consumption on the adipose tissue-liver axis to explore the role of alcohol consumption in the crosstalk between adipose tissue and the liver.
根据世界卫生组织的数据，2016 年全球约有 300 万人因饮酒而死亡，其中约 50%与肝病有关。酒精摄入干扰脂肪细胞的正常功能，这对酒精性肝病的发病机制有重要影响。近年来，人们越来越认识到脂肪组织在调节全身代谢方面的关键作用，远远超出了作为惰性储能器官的作用。脂肪组织的内分泌功能已得到广泛认可，其产生和释放的蛋白质的意义仍在研究中。酒精摄入可能会影响白色脂肪组织 (WAT) 和棕色脂肪组织 (BAT)，这两种组织与肝脏和肠道等周围组织相互作用。这篇综述简要介绍了脂肪组织的基本概念和分类，并总结了酒精影响 WAT 和 BAT 中脂肪分解和脂肪生成的机制。脂肪组织-肝脏轴对于维持体内脂质平衡至关重要。因此，本综述还展示了酒精摄入对脂肪组织-肝脏轴的影响，以探讨酒精摄入在脂肪组织与肝脏之间的相互作用中的作用。
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