U R, Hiraoka M, Takahashi M, Abe M, Matsuda T, Sugiyama A, Nakada Y, Yamamoto I, Sugahara T
Med Instrum. 1984 May-Jun;18(3):181-6.
Basic and clinical evidence that hyperthermia with radiation therapy or selected chemotherapy could significantly improve therapeutic ratios has attracted considerable interest. A variety of heating equipment and techniques have been used in many early clinical studies, with encouraging results: 60-70% with complete tumor regression without concomitant increase of normal-tissue toxicity. New generations of hyperthermia systems being developed should improve results significantly. However, since tumor response is directly related to hyperthermic temperature and the uniformity of the temperature distribution within target tissues, adequate characterization of the temperature profile within tumors as well as normal tissues is of primary importance. Clinical experience with microwave hyperthermia treatment combined with radiotherapy has been encouraging (complete regression response rate of 68% in 63 tumors in 50 patients) at Duke and VA Medical Centers, as have the results obtained (complete regression in 21 of 40 tumors treated in one clinic; 13 of 20 tumors treated in another clinic) with an 8-MHz RF capacitive hyperthermia system being evaluated in Japan.
热疗联合放射治疗或特定化疗可显著提高治疗比率的基础和临床证据引起了广泛关注。在许多早期临床研究中使用了各种加热设备和技术，结果令人鼓舞：60%至70%的肿瘤完全消退，同时正常组织毒性并未增加。正在研发的新一代热疗系统应能显著改善治疗效果。然而，由于肿瘤反应与热疗温度以及靶组织内温度分布的均匀性直接相关，充分了解肿瘤以及正常组织内的温度分布至关重要。杜克大学和弗吉尼亚州医疗中心的微波热疗联合放射治疗的临床经验令人鼓舞（50例患者的63个肿瘤的完全消退反应率为68%），日本正在评估的8兆赫兹射频电容式热疗系统所取得的结果（一个诊所治疗的40个肿瘤中有21个完全消退；另一个诊所治疗的20个肿瘤中有13个完全消退）也是如此。
