诱变阻断剂油酸无法预防大鼠结肠癌的发生。
Inability of the mutagen-blocking agent oleic acid to protect against colon carcinogenesis in the rat.
作者信息
Nelson R L, Samelson S L
出版信息
Mutat Res. 1984 Jun-Jul;140(2-3):155-7. doi: 10.1016/0165-7992(84)90061-7.
PMID:6749174
Abstract
Oleic acid has been found in cooked beef and human feces. It has also been found to protect against mutagenesis as measured by the Salmonella microsomal assay test. Addition of oleic acid to the diet of rats treated with 1,2-dimethylhydrazine, a colon carcinogen, failed to protect the rats against the induction of colon cancer.
摘要
油酸已在熟牛肉和人类粪便中被发现。通过沙门氏菌微粒体试验检测发现，它还具有抗诱变作用。在给用结肠癌致癌物1,2 - 二甲基肼处理的大鼠的饮食中添加油酸，未能保护大鼠免受结肠癌的诱发。
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