粪便pH值在实验性结肠癌发生中的保护作用。
Protective role of faecal pH in experimental colon carcinogenesis.
作者信息
Samelson S L, Nelson R L, Nyhus L M
出版信息
J R Soc Med. 1985 Mar;78(3):230-3. doi: 10.1177/014107688507800311.
Abstract
There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.
摘要
有流行病学证据表明，粪便pH值呈碱性的人群患结肠癌的风险高于粪便pH值呈酸性的人群。利用大鼠二甲基肼结肠癌发生模型在实验室中对这种关联进行了研究。通过食用乳果糖或硫酸钠或两者来产生粪便pH值呈酸性的大鼠，在注射二甲基肼（DMH）后，其结肠肿瘤明显少于仅用DMH处理的大鼠。结果证实了粪便酸化可预防结肠癌发生的假说。
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