Wilhelmsen L, Svärdsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G
N Engl J Med. 1984 Aug 23;311(8):501-5. doi: 10.1056/NEJM198408233110804.
To study the possible risk factors for cardiovascular disease, we collected data on plasma levels of coagulation factors, blood pressure, serum cholesterol, and smoking in a random sample of 792 men 54 years of age. During 13.5 years of follow-up, myocardial infarction occurred in 92 men, stroke in 37, and death from causes other than myocardial infarction or stroke in 60. The blood pressure, degree of smoking, serum cholesterol, and fibrinogen level measured at the base-line examination proved to be significant risk factors for infarction by univariate analyses during follow-up, and blood pressure and fibrinogen were risk factors for stroke. Fibrinogen and smoking were strongly related to each other. The relation between fibrinogen and infarction, and between fibrinogen and stroke, became weaker when blood pressure, serum cholesterol, and smoking habits were taken into account, but was still significant for stroke. Although causality cannot be inferred from these data, it is possible that the fibrinogen level plays an important part in the development of stroke and myocardial infarction.
为研究心血管疾病的可能危险因素，我们收集了792名54岁男性随机样本的凝血因子血浆水平、血压、血清胆固醇及吸烟情况的数据。在13.5年的随访期间，92名男性发生心肌梗死，37名发生中风，60名死于心肌梗死或中风以外的原因。基线检查时测得的血压、吸烟程度、血清胆固醇及纤维蛋白原水平经随访期间的单因素分析证明是梗死的显著危险因素，血压和纤维蛋白原是中风的危险因素。纤维蛋白原与吸烟密切相关。当考虑血压、血清胆固醇及吸烟习惯时，纤维蛋白原与梗死之间以及纤维蛋白原与中风之间的关系变弱，但对中风仍具有显著性。尽管无法从这些数据推断因果关系，但纤维蛋白原水平可能在中风和心肌梗死的发生中起重要作用。
