Cramp D G
Crit Rev Clin Lab Sci. 1982;17(1):77-101. doi: 10.3109/10408368209107033.
Hyperlipidemia is common in patients with renal disease. This fact may be of great clinical relevance in view of the overwhelming evidence associating disturbed lipid metabolism and atherogenesis. Thus, hyperlipidemia may predispose to vascular disease in patients with chronic renal disorders and premature atherosclerosis could be an important risk in renal disease and a major factor limiting survival of patients on long-term maintenance hemodialysis. The aim of the present review is to present a brief but clinically relevant description of lipoprotein physiology and then to survey the now considerable literature concerned with lipoprotein and thus lipid abnormalities in patients with renal disease. A particular emphasis is placed on the role of the plasma lipoproteins in forming an integrated and controlled pathway for lipid metabolism, and how altered regulatory control within the pathway may be associated with pathogenic mechanisms. Finally, the evidence for accelerated development of vascular disease associated with these lipid abnormalities is briefly considered.
高脂血症在肾病患者中很常见。鉴于大量证据表明脂质代谢紊乱与动脉粥样硬化形成相关，这一事实可能具有重大的临床意义。因此，高脂血症可能使慢性肾病患者易患血管疾病，而动脉粥样硬化过早发生可能是肾病的一个重要风险，也是限制长期维持性血液透析患者生存的主要因素。本综述的目的是简要介绍脂蛋白生理学，但要与临床相关，然后综述目前有关肾病患者脂蛋白及脂质异常的大量文献。特别强调血浆脂蛋白在形成脂质代谢的整合和受控途径中的作用，以及该途径内调节控制的改变可能如何与致病机制相关联。最后，简要考虑与这些脂质异常相关的血管疾病加速发展的证据。
