Bobbioni E, Jeanrenaud B
Int J Obes. 1982;6 Suppl 1:21-5.
Among the several possible mechanisms responsible for hyperinsulinemia of obese rodents, an abnormal CNS-endocrine pancreas axis has been postulated. This axis appears to involve neural (parasympathetic, sympathetic) relationships. A humoral link between the CNS and the pancreas could also exist, as based on data from these and other laboratories. Indeed, CNS sites such as the ventrolateral, the ventromedial hypothalamus or the neurointermediate lobe of the pituitary, have been shown to contain substances possessing insulin secretion modulating activity. The precise nature of these substances has yet to be determined, as well as their ability to actually be released into the systemic circulation.
在导致肥胖啮齿动物高胰岛素血症的几种可能机制中，有人提出存在异常的中枢神经系统 - 内分泌胰腺轴。该轴似乎涉及神经（副交感神经、交感神经）关系。根据这些实验室和其他实验室的数据，中枢神经系统与胰腺之间也可能存在体液联系。实际上，诸如腹外侧、腹内侧下丘脑或垂体神经中间叶等中枢神经系统部位，已被证明含有具有胰岛素分泌调节活性的物质。这些物质的确切性质以及它们实际释放到体循环中的能力尚待确定。
