Batsakis J G, Rice D H, Howard D R
Head Neck Surg. 1982 Jul-Aug;4(6):499-513. doi: 10.1002/hed.2890040609.
The term spindle cell lesion, or tumor, is a purely descriptive one and if applied without further qualification is meaningless as a guide to therapy and prognosis. The three lesions presented in this report--sarcomatoid carcinomas, nodular fasciitis, and fibrosarcoma--serve to illustrate this point. One, the sarcomatoid carcinoma, is an epithelial malignancy in which the majority of the sarcoma-like spindle cells are believed to be variants of the epithelial cells. Nodular fasciitis, a self-limited and benign soft tissue lesion, is composed principally of myofibroblasts. Primarily an extramucosal lesion, it presents a pseudosarcomatous microscopic appearance. Fibrosarcomas represent the other end of the spindle cell lesion spectrum in that they are soft tissue malignancies of fibroblastic origin. Clinical, pathologic, and biologic implications of these lesions when they arise in the mucosae of the upper aerodigestive tracts of the head and neck are presented.
梭形细胞病变或肿瘤这一术语纯粹是描述性的，如果不加进一步限定就应用它，对于治疗和预后的指导毫无意义。本报告中呈现的三种病变——肉瘤样癌、结节性筋膜炎和纤维肉瘤——用以说明这一点。其一，肉瘤样癌是一种上皮性恶性肿瘤，其中大多数肉瘤样梭形细胞被认为是上皮细胞的变体。结节性筋膜炎是一种自限性良性软组织病变，主要由肌成纤维细胞组成。它主要是一种黏膜外病变，呈现出假肉瘤样的微观外观。纤维肉瘤代表梭形细胞病变谱的另一端，因为它们是成纤维细胞起源的软组织恶性肿瘤。本文介绍了这些病变发生在头颈部上呼吸消化道黏膜时的临床、病理和生物学意义。
