Kokubu T, Kazatani Y, Hamada M, Matsuzaki K, Ito T, Nishimura K, Ochi T, Daimon F, Joh T
Jpn Circ J. 1982 Oct;46(10):1095-7. doi: 10.1253/jcj.46.1095.
Several vasodilating agents have been used for the treatment of primary pulmonary hypertension (PPH). However, no effective therapy is currently available for this distressful disease. We tried to use an angiotensin-I converting enzyme inhibitor, captopril, for one woman suffering from PPH. Her initial treatment with furosemide, digoxin and spironolactone had shown little effect. Further administration of captopril improved her clinical condition from NYHA IV to II and made it possible to treat her at our out-clinic. No adverse effect has been found. We would like to appreciate captopril as one of the effective drugs in the treatment of PPH.
几种血管扩张剂已被用于治疗原发性肺动脉高压（PPH）。然而，目前尚无针对这种令人痛苦的疾病的有效治疗方法。我们尝试对一名患有PPH的女性使用血管紧张素转换酶抑制剂卡托普利。她最初使用呋塞米、地高辛和螺内酯治疗效果甚微。进一步给予卡托普利后，她的临床状况从纽约心脏协会（NYHA）心功能IV级改善至II级，使其能够在我们的门诊接受治疗。未发现不良反应。我们认为卡托普利是治疗PPH的有效药物之一。
