离体搏动灌注大鼠主动脉前列环素的生成
Prostacyclin production of the isolated pulsatingly perfused rat aorta.
作者信息
Quadt J F, Voss R, ten Hoor F
出版信息
J Pharmacol Methods. 1982 Jun;7(4):263-70. doi: 10.1016/0160-5402(82)90079-1.
PMID:6750245
Abstract
The abdominal aorta of the rat was isolated and perfused. Pulsations were found to be a prerequisite for prostacyclin production in the isolated aorta. In the pulsatingly perfused aorta, the prostacyclin production decreases rapidly during the first 30 min of perfusion and very slowly between 30 and 120 min. The technique offers a good means of investigating the effects of different agents on prostacyclin production.
摘要
分离并灌注大鼠的腹主动脉。发现搏动是离体主动脉中前列环素产生的一个先决条件。在搏动灌注的主动脉中，前列环素的产生在灌注的前30分钟内迅速下降，在30至120分钟之间下降非常缓慢。该技术为研究不同药物对前列环素产生的影响提供了一种很好的方法。
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