• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

通过血小板聚集试验对离体灌注大鼠肺脏产生前列环素(PGI2)进行的验证。

Demonstration of PGI2 production by isolated perfused rat lungs with platelet aggregation test.

作者信息

Hartiala J, Toivonen H, Uotila P

出版信息

Prostaglandins. 1980 Jul;20(1):127-34. doi: 10.1016/0090-6980(80)90012-x.

DOI:10.1016/0090-6980(80)90012-x
PMID:6996035
Abstract

Platelet aggregation test was used for PGI2 measurements. The use of 6 % CO2 in air stabilized human platelet rich plasma (PRP) so that it could be used for up to 7 hours in these measurements. The PGI2 caused inhibition of aggregation in response to ADP was concentration dependent in the range of 0.5 ng/ml to 50 ng/ml. Isolated perfused rat lungs released spontaneously 190 ng/min PGI2 and about 3 % of infused arachidonic acid potassium salt (equivalent to 25 microgram/min arachidonic acid) was converted to PGI2.

摘要

血小板聚集试验用于测量前列环素(PGI2)。在空气中使用6%的二氧化碳来稳定人富血小板血浆(PRP),以便在这些测量中其可使用长达7小时。在0.5纳克/毫升至50纳克/毫升的范围内,PGI2对二磷酸腺苷(ADP)诱导的血小板聚集的抑制作用呈浓度依赖性。离体灌注的大鼠肺脏自发释放190纳克/分钟的PGI2,并且注入的花生四烯酸钾盐的约3%(相当于25微克/分钟的花生四烯酸)被转化为PGI2。

相似文献

1
Demonstration of PGI2 production by isolated perfused rat lungs with platelet aggregation test.通过血小板聚集试验对离体灌注大鼠肺脏产生前列环素(PGI2)进行的验证。
Prostaglandins. 1980 Jul;20(1):127-34. doi: 10.1016/0090-6980(80)90012-x.
2
[The modification of the biosynthesis and effect of thromboxane A2 and prostacyclin by trapidil (Rocornal)].曲匹地尔(心可定)对血栓素A2和前列环素生物合成及作用的影响
Biomed Biochim Acta. 1983;42(2-3):283-99.
3
The effect of ibuprofen dose on rabbit platelet aggregation and aortic pgi2 synthesis.布洛芬剂量对兔血小板聚集和主动脉前列环素合成的影响。
Thromb Res. 1982 Nov 15;28(4):581-5. doi: 10.1016/0049-3848(82)90173-6.
4
The effects of continuous infusions of prostacyclin-Na (epoprostenol-sodium) on platelet counts, ADP-induced aggregation, and cyclic AMP levels in normal volunteers.
Prostaglandins. 1983 Aug;26(2):287-302. doi: 10.1016/0090-6980(83)90096-5.
5
Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447.MK-447对离体大鼠主动脉内源性前列环素生成的促进作用。
Jpn J Pharmacol. 1981 Oct;31(5):845-8. doi: 10.1254/jjp.31.845.
6
Prostaglandins as inhibitors of human platelet aggregation.前列腺素作为人类血小板聚集的抑制剂。
Br J Haematol. 1979 Dec;43(4):637-47. doi: 10.1111/j.1365-2141.1979.tb03797.x.
7
Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides.脂肪酸氢过氧化物增强豚鼠离体灌流肺中过敏介质的释放
Prostaglandins. 1978 Aug;16(2):163-77. doi: 10.1016/0090-6980(78)90019-9.
8
Exposure to carbon monoxide or to nicotine does not inhibit PGI2 formation by rat arterial rings incubated with human platelet-rich plasma.将大鼠动脉环与人富含血小板血浆一起孵育时,暴露于一氧化碳或尼古丁并不会抑制前列环素(PGI2)的生成。
Artery. 1982;10(6):412-9.
9
Influence of pH on the prostacyclin (PGI2) mediated inhibition of platelet function.pH对前列环素(PGI2)介导的血小板功能抑制作用的影响。
Prostaglandins Med. 1980 Apr;4(4):263-73. doi: 10.1016/0161-4630(80)90021-x.
10
Combined effect of prostaglandins and an aortic proteoglycan on platelet aggregation and plasma clotting.前列腺素与主动脉蛋白聚糖对血小板聚集和血浆凝血的联合作用。
Prostaglandins Med. 1979 Sep;3(3):159-66. doi: 10.1016/0161-4630(79)90099-5.