Clift R A, Buckner C D, Thomas E D, Sanders J E, Stewart P S, Sullivan K M, McGuffin R, Hersman J, Sale G E, Storb R
Leuk Res. 1982;6(3):401-7. doi: 10.1016/0145-2126(82)90104-7.
Six fractionated total body irradiation (TBI) regimens given over 2-7 days to a total midline dose of between 1200 and 1750 rads were evaluated in 41 patients with acute lymphoblastic leukemia in relapse. Cyclophosphamide 120 mg/kg was given prior to TBI in all cases, and dimethylbusulphan was added to cyclophosphamide and 1500 rad TBI in one regimen. Relapses occurred in all regimens. The overall disease-free survival of three of 41 patients was not different from previous studies with 1000 rad TBI given in a single dose. Graft-vs-host disease occurred in only 12 of 41 patients. Two of three disease-free survivors had significant graft-vs-host disease.
对41例复发的急性淋巴细胞白血病患者评估了6种在2 - 7天内给予的分次全身照射（TBI）方案，中线总剂量在1200至1750拉德之间。所有病例在TBI之前均给予120毫克/千克的环磷酰胺，在一种方案中，将二甲磺酸丁酯添加到环磷酰胺和1500拉德TBI中。所有方案均出现复发。41例患者中有3例的总体无病生存率与之前单次给予1000拉德TBI的研究无差异。41例患者中只有12例发生移植物抗宿主病。3例无病生存者中有2例有明显的移植物抗宿主病。
