Seignalet J, Mourad G, Mion C
Nephrologie. 1982;3(2):73-9.
For the immunologic selection of donors and recipients in renal transplantation, several antigens must be considered: ABO and Lewis antigens identified by red cell typing, HLA-A, HLA-B and HLA-DR antigens identified by leucocyte typing and HLA-D antigens explored by mixed lymphocyte reaction (MLR). In renal grafts with living related donor, the best donor is ABO compatible, HLA-A and B identical, MLR negative with the recipient. In renal grafts with cadaver donor, the best recipient is ABO and Lewis compatible and must present the greatest number of HLA-A, B and DR identities with the donor. The number of cadaver donors is relatively small and the selected recipient does not however present a good HLA compatibility with his donor.
在肾移植中进行供体和受体的免疫学选择时,必须考虑几种抗原:通过红细胞分型鉴定的ABO和Lewis抗原、通过白细胞分型鉴定的HLA - A、HLA - B和HLA - DR抗原以及通过混合淋巴细胞反应(MLR)检测的HLA - D抗原。在有活体亲属供体的肾移植中,最佳供体是ABO血型相容、HLA - A和B相同且与受体MLR阴性。在有尸体供体的肾移植中,最佳受体是ABO和Lewis血型相容,并且必须与供体有最多数量的HLA - A、B和DR相同位点。尸体供体的数量相对较少,然而所选受体与他的供体的HLA相容性并不理想。