Albrechtsen D, Flatmark A, Halvorsen S, Jervell J, Solheim B G, Thorsby E
Scand J Urol Nephrol Suppl. 1980;54:25-8.
Prospective HLA-DR typing and B cell cross-match tests were performed in 177 cadaveric transplants using a modified NIH technique, 24 selected HLA-DR typing sera and B cells separated from peripheral blood in recipients and from spleen in donors. Actuarial graft survival after one year was 60% in HLA-DR compatible transplants and 30% and 18% in transplants mis-matched for 1 and 2 HLA-DR antigens. The favorable prognostic influence of HLA-DR compatibility was observed both among HLA-A, -B compatible and incompatible transplants. Sharing of HLA-DR antigen(s) between donor and recipient was also prognostically beneficial. Standard cross-match tests were negative in all transplants. B cell cross-match tests were positive in 17 cases, and one of these transplants was very acutely rejected. Actuarial graft survival after three months was 35% in B cell cross-match positive grafts versus 53% in negative ones.
采用改良的国立卫生研究院技术，对177例尸体移植进行了前瞻性HLA - DR分型和B细胞交叉配型试验，使用24种选定的HLA - DR分型血清以及从受者外周血和供者脾脏中分离出的B细胞。在HLA - DR配型相合的移植中，一年后的实际移植物存活率为60%，在HLA - DR抗原错配1个和2个的移植中分别为30%和18%。在HLA - A、- B配型相合和不相合的移植中均观察到HLA - DR配型相合对预后的有利影响。供者与受者之间HLA - DR抗原的共享在预后方面也有益处。所有移植的标准交叉配型试验均为阴性。B细胞交叉配型试验在17例中呈阳性，其中1例移植发生了非常急性的排斥反应。B细胞交叉配型阳性的移植物三个月后的实际移植物存活率为35%，而阴性者为53%。
