Hoffman W E, Albrecht R F, Pelligrino D, Miletich D J
Prostaglandins. 1982 Jun;23(6):897-905. doi: 10.1016/0090-6980(82)90132-0.
The role of prostaglandins in producing cerebrovasodilation during hypercapnia was tested in goats. Cerebral blood flow (CBF) changes with increasing arterial PCO2 were measured before and after prostaglandin synthesis inhibition with indomethacin or ibuprofen. Both drugs produced significant decreases in CBF under control anesthetized conditions but had no significant effect on the cerebrovascular response to increased arterial PCO2. The effects of direct intracerebrovascular infusion of prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha) and prostacyclin were also measured. In the dose range tested (0.1-1) microgram/min) PGF2 alpha had no significantly greater than that produced by PGE2. The effectiveness of each compound in producing cerebrovascular changes is consistent with the endogenous distribution of prostaglandins within the brain. These results suggest that prostaglandins, particularly PGI2, may be important in modulating cerebrovascular tone but have no role in increasing CBF during hypercapnia.
在山羊身上测试了前列腺素在高碳酸血症时产生脑血管舒张中的作用。在用吲哚美辛或布洛芬抑制前列腺素合成前后，测量了随着动脉血二氧化碳分压升高时脑血流量（CBF）的变化。在对照麻醉条件下，两种药物均使CBF显著降低，但对脑血管对动脉血二氧化碳分压升高的反应无显著影响。还测量了直接脑血管内输注前列腺素E2（PGE2）、前列腺素F2α（PGF2α）和前列环素的作用。在测试的剂量范围内（0.1 - 1微克/分钟），PGF2α产生的脑血管变化并不显著大于PGE2产生的变化。每种化合物产生脑血管变化的有效性与前列腺素在脑内的内源性分布一致。这些结果表明，前列腺素，尤其是前列环素，可能在调节脑血管张力中起重要作用，但在高碳酸血症期间对增加CBF无作用。
