Ohneda A, Kobayashi T, Nihei J
Tohoku J Exp Med. 1982 Aug;137(4):437-44. doi: 10.1620/tjem.137.437.
In order to evaluate the validity of recently proposed criteria for diagnosis of diabetes mellitus, a retrospective study was performed in 315 patients with borderline diabetes, who were selected from approximately 4,000 outpatients under treatment for more than three years. They were divided into two groups, BI and BII, according to the 2-hr blood glucose level in the 50 g glucose tolerance test (GTT): BI between 100 and 135 mg/100 ml and BII between 135 and 195 mg/100 ml. In group BI, glucose tolerance was deteriorated in 38 of 75 patients (51%) and converted to diabetes mellitus in 21 patients (28%). In group BII, 78 among 232 patients (34%) developed diabetes mellitus. Furthermore, in 85% of the 99 cases of the conversion to diabetes mellitus from borderline diabetes, it occurred within 5 years. Diabetic retinopathy was observed in 25 of 72 patients (35%) in group BI and in 60 of 212 patients (28%) in group BII. More than two thirds of the patients with diabetic retinopathy observed in the borderline diabetes developed their retinopathy within 5 years. Normal insulin response during GTT was proved only in 21% and 17% among groups BI and BII, respectively. These results indicate that the patients with borderline diabetes BI as well as BII, are closely related with diabetes mellitus, and that the patients with impaired glucose tolerance should be treated with diet restriction as in diabetes mellitus.
为评估最近提出的糖尿病诊断标准的有效性，对315例临界糖尿病患者进行了一项回顾性研究，这些患者是从大约4000名接受治疗三年以上的门诊患者中挑选出来的。根据50克葡萄糖耐量试验（GTT）中的2小时血糖水平，将他们分为两组，BI组和BII组：BI组血糖水平在100至135毫克/100毫升之间，BII组在135至195毫克/100毫升之间。在BI组中，75例患者中有38例（51%）糖耐量恶化，21例（28%）转变为糖尿病。在BII组中，232例患者中有78例（34%）发展为糖尿病。此外，在从临界糖尿病转变为糖尿病的99例病例中，85%发生在5年内。在BI组的72例患者中有25例（35%）观察到糖尿病视网膜病变，在BII组的212例患者中有60例（28%）观察到糖尿病视网膜病变。在临界糖尿病中观察到的糖尿病视网膜病变患者，超过三分之二在5年内出现视网膜病变。在GTT期间，BI组和BII组中胰岛素反应正常的患者分别仅为21%和17%。这些结果表明，临界糖尿病患者BI组和BII组都与糖尿病密切相关，并且糖耐量受损的患者应像糖尿病患者一样进行饮食限制治疗。
