Some reactions of influenza viruses adsorbed to polystyrene for enzyme immunoassay.

Three influenza viruses adsorbed to the surface of polystyrene tubes exhibited the property of haemadsorption, but only two of the neuraminidases were still active. Reactions of the viruses with rabbit antisera indicated that at least some of the virus particles were ruptured by adsorption to the polystyrene and the exposed nucleoprotein could react with antibody. Enzyme immunoassays involving direct adsorption of influenza virus particles to polystyrene are unlikely, therefore, to differentiate between strains of influenza A.