初次感染流感病毒期间小鼠肺内流感病毒特异性抗体分泌细胞
Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection.
作者信息
Jones P D, Ada G L
出版信息
J Virol. 1986 Nov;60(2):614-9. doi: 10.1128/JVI.60.2.614-619.1986.
Abstract
An enzyme-linked immunosorbent plaque assay is described which can reliably enumerate influenza virus-specific antibody-secreting cells and exhibits specificity similar to that of the indirect enzyme-linked immunosorbent assay. The assay was used to characterize the development of specific antibody-secreting cells, principally within lung tissue, during primary murine influenza virus infection after intranasal inoculation. Cells secreting influenza virus-specific immunoglobulin M (IgM), IgG, and IgA were detected in greatest numbers in lung tissue, and the data presented indicated that the cells may have originated from specific B-cell precursors in lung tissue which are demonstratable in vitro. At 11 months after infection, cells secreting IgG and IgA were still present in lung tissue. Influenza virus-specific antibody-secreting cells were also detected in spleen tissue and blood. Antibody-secreting cells appeared earlier in spleen than in lung tissue and declined more rapidly in spleen tissue.
摘要
本文描述了一种酶联免疫吸附斑试验，该试验能够可靠地计数流感病毒特异性抗体分泌细胞，并且具有与间接酶联免疫吸附试验相似的特异性。该试验用于表征在小鼠经鼻接种原发性流感病毒感染期间，主要在肺组织内特异性抗体分泌细胞的发育情况。在肺组织中检测到分泌流感病毒特异性免疫球蛋白M（IgM）、IgG和IgA的细胞数量最多，所呈现的数据表明这些细胞可能起源于肺组织中可在体外证明的特异性B细胞前体。感染11个月后，肺组织中仍存在分泌IgG和IgA的细胞。在脾组织和血液中也检测到了流感病毒特异性抗体分泌细胞。抗体分泌细胞在脾中比在肺组织中出现得更早，并且在脾组织中下降得更快。
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